From 1902 she had a studio in Kensington and pursued a dual career as painter and illustrator of fine colour-printed editions of literary texts such as Tennyson's Poems (1905) and Palgrave's Golden Treasury (1925); these being accompanied by regular exhibitions at Dowedeswell and Leicester Galleries of the original watercolours.
Having personal connections with the aviator Charles Rolls, she took an interest in aeroplane technology, manifested in a large memorial picture to Rolls and The Forerunner (1920) depicting Leonardo da Vinci and his model flying machine. Brickdale was the first female member of the Institute of Painters in Oils, 1902, and a member of the RWS from 1903; she also taught for some years at the Byam Shaw School of Art.
In later years her style broadened, and she also designed for stained-glass. Her professional career ended in 1938 when she suffered a stroke. She died in London in 1945.